the major ones being hormones and age, although stress and other factors yet undetermined, may play a role. None of the genes responsible for male pattern baldness have yet been identified. This suggests that any kind of genetic engineering to prevent common baldness is still many years away. Even if the gene is identified, scientists must still figure out how to control or change them.
PUBLISHERS NOTE: Single copies of this article can be downloaded and printed only for the reader’s personal research and study. Synopsis: “Surgery of the Skin: Procedural Dermatology,” covers the entire range of dermatologic surgical procedures. It was conceived to be used as the core surgical textbook for dermatologic training programs. Dr. Bernstein’s chapter on follicular unit hair transplantation covers a wide range of subjects including the history of follicular unit hair transplantation, evaluating the patient, planning the surgery, setting-up the operating room, and maximizing the cosmetic outcome of the hair restoration. Specific topics include the techniques of Follicular Unit Transplantation including density assessment, single-strip harvesting, follicular unit extraction, anesthetic use, aesthetic design and many other important topics.
ast some degree of genetic hair thinning or balding by the time they reach their 50s. Whether it begins with a receding hairline or a thinning crown, male pattern baldness is a common concern, and one that can now be addressed with advanced, proven methods that target men's hair loss.
The FDA approval of oral finasteride, in the form of Propecia, has been a major breakthrough in the medical management of male pattern baldness. Before Propecia, the only medically proven treatment was topical minoxidil (Rogaine) and this medication was only minimally effective and, for many, a nuisance to apply. Propecia, on the other hand, is a once-a-day pill that can significantly alter the progression of genetic balding, particularly if started when the hair loss is still in its early stages. The recent availability of finasteride in a generic, 5mg tablet, has decreased the cost of the drug – for those who don't mind cutting up pills. Avodart (dutasteride), a more potent medication that is related to finasteride, has been approved for the treatment of prostate enlargement, but not hair loss. Because of its affect on the balding process we will discuss this medication as well.
the affects of DHT. It is characterized the replacement of thick terminal hairs with fine, miniaturized hairs that are eventually lost. Also termed female pattern baldness, male pattern baldness, hereditary alopecia and simply common baldness.
e to hair loss in some individuals. It is of interest that, although genes for some types of hair loss have been mapped, the genes responsible for male pattern baldness have yet to be fully identified. This suggests that any kind of genetic engineering to prevent common baldness is still many, many years away. In summary, Androgenetic alopecia is felt to be a “dominant” genetic trait that is passed down from your mother or father, but with a slight predisposition to the maternal side due to the presence of an important androgen receptor gene on the X chromosome. In order for hair loss to become apparent, the trait must be expressed – through changes in the production of hormones or changes due to the aging process.
Q: What is Lichen planopilaris? -- G.S., Pleasantville, NY A: Lichen planopilaris (LPP) is a distinct variant of cicatricial (scarring) alopecia, a group of uncommon disorders which destroy the hair follicles and replace them with scar tissue. LPP is considered to have an autoimmune cause. In this condition, the body’s immune system attacks the hair follicles causing scarring and permanent hair loss. Clinically, LPP is characterized by the increased spacing of full thickness terminal hairs (due to follicular destruction) with associated redness around the follicles, scaling and areas of scarred scalp. Read more ».
nsplanted scalp with a thin or balding crown is a pattern acceptable for an adult, but totally unsuitable for a person in his twenties. ((Norwood OT. Male pattern baldness: classification and incidence. So. Med. J 1975; 68:1359-1365.)) In addition, if the donor area were to thin over time, the donor scar might become visible if the hair were worn short – a style that is much more common in people who are young.
medication that blocks the conversion of testosterone to dihydrotestosterone (DHT), the hormone largely responsible for prostate enlargement and for male pattern baldness. It does this by inhibiting the action of both types (Type I and II) 5-alpha reductase enzyme. In contrast, finasteride, the FDA approved medication for hair loss, inhibits only the Type II enzyme, the enzyme that is present in highest concentrations in and around the hair follicles. Both dutasteride and finasteride produce a rapid decrease in serum DHT concentration. Lowering DHT appears to inhibit the miniaturization (shrinking) of affected hair follicles and helps restore miniaturized hair follicles to regrow visible hair. Dutasteride (Avodart) inhibits both type I and type II, 5a-reductase. At the 0.5-mg dose, it is about 3 times as potent as finasteride at inhibiting type II, 5?-reductase enzyme and more than 100 times as potent at inhibiting the type I 5?-reductase enzyme. Type I receptors inhibited by dutasteride are present in other organs of the body besides the skin, including the liver and kidneys.