Posts Tagged: Diffuse Unpatterned Alopecia (DUPA)

Can Stress Cause Diffuse Unpatterned Hair Loss (DUPA)?

October 30th, 2007

Q: Can stress produce diffuse unpatterned hair loss (DUPA), or was it bound to happen anyway?

A: Both DPA (diffuse patterned hair loss) and DUPA (diffuse unpatterned hair loss) are genetic conditions, unrelated to stress and would have happened anyway. These types of hair loss are characterized by a high percentage of mininiaturized hair in broad areas of the scalp. See the Classification of Hair Loss in Men and Classification of Hair Loss in Women pages on the Bernstein Medical – Center for Hair Restoration website for more information on this topic.

In contrast, stress generally presents as increased hair shedding, a reversible condition referred to as telogen effluvium. It is called this because the normal growing hair is shifted to a resting (telogen) phase before it temporarily falls out. Increased miniaturization is not associated with telogen effluvium.


Posted by Robert M. Bernstein M.D. at 8:24 am

What Age is Appropriate for Hair Transplant in Person With Early Hair Loss?

March 30th, 2007

Q: My hair is receding in the front corners and I have a spot in the crown. I am 22 years old. I’ve been thinking of hair transplants for the past few years and I am 100% sure I want to take this step. I don’t go anywhere without my hat. I hate it. Should I consider hair transplants now?

A: We generally do not consider hair transplantation until a person is at least 25. There are a number of reasons why hair transplants are not indicated in someone younger than this.

When hair loss starts at an early age, the pattern is unpredictable and the hair loss has a greater chance of being extensive in the future. Also, the permanency of the donor area cannot be determined (see the Diffuse Unpatterned Alopecia (DUPA) page on the Bernstein Medical – Center for Hair Restoration website).

If hair loss is going to be extensive, then the best that one can expect from a hair transplant is to replace hair on the front and top of the scalp. There would usually not be enough hair to fill in the temples or the crown. This look is fine for a person in their 30’s or 40’s who is losing hair, but having a thin or bald crown is not generally acceptable for someone in their 20’s.

Hair transplants are more efficient if performed in relatively large sessions. Multiple, small incisions in the back of the scalp (either by Follicular Unit Transplantation (FUT) or Follicular Unit Extraction (FUE)) consume more hair than when the hair is harvested through a single incision. In addition, when hair loss is early and there is a lot of miniaturized hair in the area to be transplanted, the hair transplants can actually accelerate hair loss in the area in the vicinity of the procedure.

If one were to try and fill in the temples of a young person, a substantial amount of hair would be needed so that the density of the transplanted hair would match the density of the surrounding (already existing) hair. As the person continued to lose hair in the center, the densely transplanted hair in the temples would stand out as two permanent “horns” of hair. Hair placed in the crown would create the same problem, as enough density to satisfy a young person would result in a pony tail as the hair loss in the crown progressed and the bald area expanded around the transplanted area. With advanced baldness, there may not be enough donor hair to connect these areas together, so the result will be a very unnatural look.

In the adult male, the frontal hairline is normally recessed at the temples, so this should not be restored unless the patient’s donor density is very high and the ultimate hair loss pattern limited – two conditions that cannot be determined when a person is young.

On the other hand, medical therapy with finasteride (Propecia) can be very effective in early hair loss by possibly growing some hair back and more importantly by slowing or halting the balding process for many years. The sooner the medication is started the more useful it is, because it works far better in preventing hair loss than bringing it back once the hair is gone. Unfortunately, it will not grow hair back in the temples if this area is completely devoid of hair. Medications work by reversing the miniaturization process, so there must be some existing hair in the area for it to act on.

In sum, it is best to wait until you are a bit older before considering surgical hair restoration. By having hair transplants at a slightly older age, your expectations may be closer to what can actually be accomplished, and your eventual hair loss pattern will be easier to determine. In the meantime, medical treatment with Finasteride, is a good option.


Posted by Robert M. Bernstein M.D. at 1:24 pm

Can Propecia Hair Loss Medication Treat Diffuse Unpatterned Alopecia (DUPA)?

March 14th, 2007

Q: I am 26 and I have been diagnosed with Diffuse Unpatterned Alopecia (DUPA) and realize I am not a candidate for hair transplants. I have been on Propecia for about 9 months. There have been periods of increased shedding throughout and I am still shedding what seem to be mostly very fine, miniaturized hairs. Do you think this is the Propecia speeding up the hair cycle and pushing out the old fine hairs, or do you think this is an increase in the pace of my genetic balding? I know that your posting states that the accelerated hair loss generally stops by the 6th month. Does DUPA have any effect on the timeframe? Also, I have read that Propecia is only effective for about 50% of patients with DUPA. Do you find that to be true, or have you found a different experience?

A: It is hard to tell at 9 months whether it is shedding from the finasteride or that the medication is just not working. Since there is no way to tell, I would stay on the medication for 2 years for any possible shedding from the medication to have passed and to see if your hair loss actually stops.

Since the natural history of DUPA is so unpredictable, I would give it the full two years rather than the 1-year trial the company recommends. There is no real scientific data to support this recommendation, however.

Please take heart in the fact that people with DUPA often look great (even without any hair transplants) if they keep their hair very short, since they never develop that cosmetically unappealing wreath of hair around the back and sides that is normally associated with extensive balding.


Posted by Robert M. Bernstein M.D. at 7:20 am

Can Hair Transplant Treat Diffuse Hair Loss in Women?

October 27th, 2006

Q: My hair loss resembles the grade I female hair loss scale, but none of the male hair loss patterns. It has been relatively stable for the past five years and only recently has it begun to progress further. I began both Propecia and regain two months ago, but the hair loss still continues at the same pace. I’m really worried. Does a hair transplant work in such a diffuse hair loss?

A: If your hair loss is diffuse only on top, then a hair transplant will be effective. This condition is called Diffuse Patterned Alopecia or DPA.

If the diffuse pattern of hair loss affects the back and sides as well, then surgical hair restoration should be avoided. In this case (called Diffuse Unpatterned Alopecia or DUPA) the donor area is not permanent and the transplanted hair will continue to thin over time.


Posted by Robert M. Bernstein M.D. at 2:02 pm

How Do You Treat Diffuse Hair Loss in Donor Area?

October 9th, 2006

Q: I underwent hair transplant surgery several years ago and was pleased with the results. However, over the last 2-3 years I’ve lost hair in the donor area with subsequent loss of hair in the transplanted area. Is this type of hair loss especially difficult to treat? What accounts for hair loss from the back of the head that is typically considered “permanent”?

A: Less than 5% of patients have unstable donor areas i.e. where the back and sides thin along with the front and top. We call this condition Diffuse Unpatterned Alopecia or DUPA.

It is best to identify this condition before hair transplant surgery is contemplated as people with DUPA are not good candidates for hair transplantation.

The diagnosis is made using densitometry by noting high degrees of miniaturized hair in the donor area.

At this point, I would use medications such as finasteride.

I would not do further hair restoration surgery.


Posted by Robert M. Bernstein M.D. at 9:45 am



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