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Bernstein Medical - Center for Hair Restoration

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Hair Restoration Research

Hair Regrowth Following a Wnt- and Follistatin-Containing Treatment

Summary of “Hair Regrowth Following a Wnt- and Follistatin-Containing Treatment: Safety and Efficacy in a First-in-man Phase 1 Clinical Trial,” which was originally published in the November 2011 issue of the Journal of Drugs in Dermatology (Volume 10, Issue 11).

Researchers were aware of the importance of follistatin, a binding protein; Wnt 7a, a signaling protein; and wound healing factors on hair growth. In this study, researchers tested the safety and efficacy of an injection of a mixture of naturally derived molecules on hair growth.

The mixture called the Hair Stimulating Complex (HSC), contained follistatin, as well as keratinocyte growth factor (KGF), and vascular endothelial growth factor (VEGF). The mixture also showed activity similar to the Wnt signaling protein.

Zimber MP, et al. 2011

Posted by Robert M. Bernstein M.D. Updated 2017-12-22
Hair Restoration Research

Hair Loss Cure A Possible Result Of Stem Cell Communication Research

Following some new research on stem cells, and their relationship with androgenetic alopecia (genetic hair loss), an article on stem cells and the way they organize hair growth was published in the April 29th issue of the journal Science. At issue is the way in which large numbers of stem cells coordinate the cycle of hair growth over thousands of hair follicles. How do all of those hair follicle stem cells know when to grow hair, and how do they know what their “neighbor” hair follicles are doing?

Chuong C, et al. 2011

Posted by Robert M. Bernstein M.D. Updated 2018-01-09
Hair Restoration Research

Dr. Christiano at Columbia University Identifies APCDD1, A Newly Discovered Gene Associated With Hair Loss

Dr. Angela Christiano of Columbia University in New York and a team of scientific researchers, have identified a new gene involved in hair growth. Their discovery may affect the direction of future research for hair loss and the diagnosis and ultimate prevention of male pattern baldness.

The condition, which leads to thinning hair, is called hereditary hypotrichosis simplex. Through the study of families in Pakistan and Italy who suffer from this condition, the team was able to identify a mutation of the APCDD1 gene located in chromosome 18. This chromosome has been linked to other causes of hair loss.

Posted by Robert M. Bernstein M.D. Updated 2013-07-08
Hair Restoration Research

Summary: Hair Follicle Regeneration in Adult Mouse Skin After Wounding

This study demonstrates that after wounding the skin of an adult mouse, an embryonic-like change in the epidermal cells outside of the hair follicle stem cells can be induced to form new hair follicle stem cells. In other words, these cells originate from epidermal skin cells in the wound, but then are able take on the characteristics of hair follicle stem cells and actually produce hair.

Posted by Robert M. Bernstein M.D. Updated 2017-11-15



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