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Hair Restoration Research

JAK Inhibitors Prove Effective in Trials on Alopecia Areata

Two new studies researching a class of drugs called JAK inhibitors have shown that oral treatment results in significant hair regrowth in patients with alopecia areata, an autoimmune condition that causes non-scarring patches of localized hair loss. Currently there is no cure for alopecia areata, so the possibility of a safe, effective medication is welcome news for thousands of affected patients. The two studies were published in September 2016 in the journal JCI Insight, a peer-reviewed journal dedicated to biomedical research.

Posted by Robert M. Bernstein M.D. Updated 2016-10-25
Hair Restoration Research

Study Identifies A Possible Cause of Age-Induced Hair Loss

We have known for decades that the incidence of male pattern baldness increases with age. New research published in the February 2016 edition of the journal Science has shed light on why this is the case. Researchers examining the role of hair follicle stem cells (HFSC) in the hair growth cycle have found that accumulated DNA damage in these cells results in the depletion of a key signaling protein and the progressive miniaturization of the hair follicle (and eventual hair loss). The study represents a breakthrough in our understanding of the cell aging process and could open new pathways for the treatment of not only hair loss, but other age-related conditions as well.

Posted by Robert M. Bernstein M.D. Updated 2017-10-06
Hair Restoration Research

Dr. Christiano Discovers JAK Inhibitors as Potential New Topical Treatment for Hair Loss

Dr. Angela Christiano and her team of researchers at Columbia University studying the autoimmune disease Alopecia areata, have shed new light on how to move hair follicles from their resting (telogen) stage into the anagen phase where they can produce normal hairs. Their study, published in the October issue of Science Advances, introduces the possibility of a new topical medication for hair growth. The finding has implications in the treatment of androgenetic alopecia (common hair loss) as well as Alopecia areata, which causes a non-scarring form of localized hair loss.

Posted by Robert M. Bernstein M.D. Updated 2016-09-20



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