dht - Bernstein Medical Center for Hair Restoration

Showing results 61 - 70 of 100 for the search term: dht.

Chapter 2 – Hair and Its Functions

tains specialized cells called fibroblasts that regulate the hair cycle and hair growth. The dermal papillae contains androgen receptors sensitive to DHT. For many years, scientists thought that hair growth originated from the dermal papillae. Recent evidence has shown that the growth center extends from the dermal papillae all the way up to the region of the follicle where the sebaceous glands are attached. It is now believed that the primary function of the dermal papillae is to regulate follicular growth and differentiation. If the dermal papillae is removed (this sometimes happens during hair transplant surgery), the hair follicle is often able to regenerate a new one, although the growth of the new hair will be delayed. The matrix sits over the dermal papillae and contains actively dividing, immunologically privileged cells. Together, the dermal papillae and the matrix are referred to as the hair bulb. The size of the bulb and the number of matrix cells will determine the width of the fully-grown hair. The cells of the matrix differentiate into the three main components of the hair follicle: ORS, IRS and hair shaft. The outer root sheath or trichelemma (Greek for coating sac), surrounds the hair follicle in the…

Read the full post

Dutasteride Info Sheet

for the treatment BPH, but not for hair loss. Dutasteride is an oral medication that blocks the conversion of testosterone to dihydrotestosterone (DHT), the hormone largely responsible for prostate enlargement and for male pattern baldness. It does this by inhibiting the action of both types (Type I and II) 5-alpha reductase enzyme. In contrast, finasteride, the FDA approved medication for hair loss, inhibits only the Type II enzyme, the enzyme that is present in highest concentrations in and around the hair follicles. Both dutasteride and finasteride produce a rapid decrease in serum DHT concentration. Lowering DHT appears to inhibit the miniaturization (shrinking) of affected hair follicles and helps restore miniaturized hair follicles to regrow visible hair. Dutasteride (Avodart) inhibits both type I and type II, 5a-reductase. At the 0.5-mg dose, it is about 3 times as potent as finasteride at inhibiting type II, 5?-reductase enzyme and more than 100 times as potent at inhibiting the type I 5?-reductase enzyme. Type I receptors inhibited by dutasteride are present in other organs of the body besides the skin, including the liver and kidneys.

Read the full post

Avodart (Dutasteride)

t/propecia-finasteride/">Propecia), dutasteride is an inhibitor of the enzyme 5 alpha-reductase responsible for the conversion of testosterone to DHT (dihydrotestosterone). However, unlike finasteride, which only inhibits the Type II form of the enzyme, dutasteride inhibits both the Type I and Type II forms of the 5 alpha-reductase enzyme. This dual effect makes the drug more potent but also increases the incidence of adverse reactions. The Type II form of the enzyme is found predominantly in the hair follicle. The Type I form of the enzyme has been found in the scalp and sebaceous glands, but its exact role in hair growth has not been determined.

Read the full post

Rogaine (Minoxidil)

ke finasteride, its effects are not related to androgens. The simultaneous use of minoxidil and finasteride (which directly inhibits the formation of DHT) may have some synergistic benefit in the treatment of hair loss, although finasteride is significantly more effective.

Read the full post

Info on Finasteride

® (finasteride 1mg) is an oral medication, manufactured by Merck Pharmaceuticals, that blocks the conversion of testosterone to dihydrotestosterone (DHT), the hormone largely responsible for male pattern baldness. It does this by inhibiting the action of the type II 5-alpha reductase enzyme that is present in higher concentration in and around the hair follicles of balding men with androgenetic alopecia. Finasteride is the only FDA approved medication for hair loss in men. It became available as the brand

Read the full post

Propecia (Finasteride)

Schedule a Consultation Overview – Male Pattern Baldness and DHT

Read the full post

Causes

tew of genes, hormones, and age. However, in women, there are even more players. In addition to 5-a reductase, testosterone, and dihydrotestosterone (DHT); which are also found in men's hair loss; also present in women are the enzyme aromatase and the female hormones estrone and estradiol. So let's break down the process that leads to common hair loss in women. In both men and women, 5-a reductase reacts with testosterone to produce DHT, the hormone responsible for the miniaturization (shrinking) and the gradual disappearance of affected hair follicles. This explains why both men and women lose their hair. But one of the reasons why women seldom have the conspicuous bald areas that men do is because women naturally have only half the amount of 5-a reductase compared to men. Adding to this complexity, in women, the enzyme aromatase is responsible for the formation of the female hormones, estrone, and estradiol, counteract the action of DHT. Women have higher levels of aromatase than men, especially at the frontal hairline. It is this presence of aromatase which may help explain why hair loss in women looks so different than in men, particularly with respect to the preservation of the frontal hairline. It…

Read the full post

Diagnosis

(left), normal scalp (right)"> Hairs may be in varying states of miniaturization, but if the follicles are continually exposed to the hormone DHT they will eventually stop producing hairs and the follicles will disappear. The diagnosis of androgenetic alopecia is supported by a family history of hair loss, although a positive history is not always identified, and the absence of other medical causes of alopecia. In older patients, their own history of passing through the different Norwood stages is strongly suggestive of male pattern alopecia.