Research and developments about the medical treatment for hair loss and related topics.

Hair Restoration Research

Viviscal May Boost Hair Regrowth

Posted by Robert M. Bernstein M.D. on February 3rd, 2016

A study published in the December 2015 issue of the Journal of Clinical and Aesthetic Dermatology suggests that Viviscal, an oral supplement designed for women with thinning hair, may promote hair growth. The researchers noted a 79 percent increase in healthy, terminal hairs and an almost 12 percent increase in hair diameter in female patients who took the supplement for six months. The evidence suggests that Viviscal may be a useful supplement to current hair restoration treatments, or an alternative treatment in patients not indicated for hair transplant surgery or medical treatment with finasteride.

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Hair Restoration Research

Viviscal Research Suggests the Treatment Increases Hair Volume, Thickness

Posted by Robert M. Bernstein M.D. on February 1st, 2016

A review of research on the efficacy of Viviscal, published in the September 2015 issue of the Journal of Drugs in Dermatology, suggests that the oral supplement may increase hair volume as well as the thickness of healthy, terminal hairs. The article presented more than two decades of research on the hair regrowth product and also included a discussion with a roundtable of dermatology and plastic surgery experts. Both the research review and roundtable discussion point to the benefits of Viviscal, however the article’s conclusions can be questioned due to the appearance of a conflict of interest between the researchers and Lifes2good, Inc., the company that produces Viviscal. Additional independent research needs to determine if Viviscal is a viable and effective hair loss treatment.

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Hair Restoration Research

Dr. Christiano Discovers JAK Inhibitors as Potential New Topical Treatment for Hair Loss

Posted by Robert M. Bernstein M.D. on November 20th, 2015

Dr. Angela Christiano and her team of researchers at Columbia University studying the autoimmune disease Alopecia areata, have shed new light on how to move hair follicles from their resting (telogen) stage into the anagen phase where they can produce normal hairs. Their study, published in the October issue of Science Advances, introduces the possibility of a new topical medication for hair growth. The finding has implications in the treatment of androgenetic alopecia (common hair loss) as well as Alopecia areata, which causes a non-scarring form of localized hair loss.

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Hair Restoration Research

Melatonin Solution Found to Reverse Early Hair Loss in Men and Women

Posted by Robert M. Bernstein M.D. on March 31st, 2015

International Journal of Trichology - Oct-Dec 2012Topical application of the solution containing melatonin, ginkgo biloba and biotin was found to reduce hair loss, and in some cases grow new hair. Incidence of seborrhea was also reduced by the treatment. While the exact mechanism for this result is unknown, if effective, it is likely related to the antioxidative effect of melatonin and/or a melatonin receptor-mediated antiandrogenic effects. More research on melatonin needs to be conducted, but this study acts as a proof of concept for the use of melatonin as a treatment for early hair loss in men and women and potentially as a treatment for seborrhea.

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Hair Restoration Research

High-Grade Prostate Cancer Risk Increases in Heavy Drinkers Who Take Dutasteride

Posted by Robert M. Bernstein M.D. on March 24th, 2015

A new 4-year study, published in the journal European Urology, found that men who take dutasteride (part of a class of medications called 5-alpha reductase inhibitors) and who also drink heavily (more than seven alcoholic drinks per week) have a greater risk of developing high-grade prostate cancer than men who take dutasteride and do not drink.

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Hair Restoration Research

Caffeine Reverses Androgenetic Alopecia, Promotes Hair Growth in Cell-Cultured Hair Follicles

Posted by Robert M. Bernstein M.D. on December 4th, 2014

Hair loss caused by androgenetic alopecia can be stopped by existing medications, but to date, only two FDA-approved drugs are available for treatment of AGA: finasteride (Proscar ®) and topical minoxidil (Rogaine®). Unfortunately, up to 3 out of 10 individuals will not respond to one or more of these drugs. Because of this, researchers have searched for alternate treatments, especially for women since finasteride is not approved for use in female patients.

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Hair Restoration Research

Does Finasteride or Dutasteride, Used for Enlarged Prostates, Cause Male Breast Cancer?

Posted by Robert M. Bernstein M.D. on July 30th, 2014

Could the 5α-reductase inhibitors (5ARIs) dutasteride and finasteride increase the risk of developing male breast cancer? A 2013 study published in the Journal of Urology found no evidence for a link between 5ARIs and male breast cancer.

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Hair Restoration Research

Erythropoietin (EPO) Found to Promote New Hair Growth & Could Help to Reverse Male Pattern Baldness

Posted by Robert M. Bernstein M.D. on July 23rd, 2014

Could a hormone that plays a critical role in red blood cell production also play a critical role in hair follicle production? According to a 2010 research report published in the Journal of Dermatological Science, this may be the case.

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Hair Restoration Research

New Arthritis Drug Reverses Baldness from Alopecia Areata

Posted by Robert M. Bernstein M.D. on July 8th, 2014

Could a recently FDA-approved drug for rheumatoid arthritis also be a cure for a common type of hair loss called alopecia areata? The drug is called Xeljanz, and that’s what Dr. Brett King, assistant professor of dermatology at Yale, is hoping.

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Hair Restoration Research

New Analysis of Scientific Studies Questions Connection Between Propecia Use and Persistent Sexual Side Effects

Posted by Robert M. Bernstein M.D. on May 28th, 2014

Recent news reports, coupled with warnings from Merck and the FDA, about Propecia’s possible persistent sexual side effects have caused growing concern about this popular hair loss treatment. An increasing number of men now fear that Propecia (finasteride 1mg) will cause permanent sexual dysfunction.

A 2014 meta-analysis, however, found that the number of self-reported cases of persistent sexual dysfunction by patients given finasteride was statistically no different from the number reported by patients given a placebo.

This latest research supports the conclusion of existing literature that there is no correlation between finasteride use and persistent or permanent sexual dysfunction. That said, this is an important issue that still needs to be studied.

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Hair Restoration Research

How Does Minoxidil Work? A Review Of Recent Research

Posted by Robert M. Bernstein M.D. on May 20th, 2014

Since 1993, minoxidil has been the most successful topical treatment for hair loss in both men and women, yet its exact mechanism of action remains unknown.

A 2004 review of minoxidil’s possible mechanisms of action (A.G. Messenger & J. Rundegren, 2004) suggests that the best evidence supports the idea that minoxidil causes hair follicles in the later phases of their resting phase (telogen) to shift prematurely into an active growth phase (anagen) sooner than they otherwise would; this causes rapid increase in hair growth. They also found good evidence that minoxidil works to thicken the hair by increasing hair diameter.

While minoxidil’s effects on other critical factors known to affect hair growth — such as cell proliferation, collagen synthesis, vascular endothelial growth factor and prostaglandin synthesis — remain uncertain, more recent research has found evidence that it may also suppress the androgen-androgen receptor responsible for androgenetic alopecia (Cheng-Lung Hsu, Jai-Shin Liu,An-Chi Lin, Chih-Hsun Yang, Wen-Hung Chung, & Wen-Guey Wu, 2014).

Understanding minoxidil’s exact mechanism of action remains today an important line of research both for the development of better hair loss treatments and for a better understanding of the biology of hair growth.

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Hair Restoration Research

Study: Finasteride Does Not Increase Mortality From Prostate Cancer

Posted by Robert M. Bernstein M.D. on August 20th, 2013

The results of an 18-year study, just published in the New England Journal of Medicine, showed that finasteride does not increase the likelihood of death from prostate cancer in men who take the drug. Early results from the same study had suggested that finasteride might increase the risk of developing higher grade tumors; however, follow-up results from the long-term study show that men taking the drug do not have an increased risk.

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Hair Restoration Research

Propecia Causes No Statistically Significant Change in Sexual Function, Says 2004 Tosti Study

Posted by Robert M. Bernstein M.D. on August 23rd, 2012

The central finding of a 2004 study led by Italian researcher Dr. Antonella Tosti, in which he and his team investigated sexual dysfunction in hair loss patients being treated for androgenetic alopecia, was that there was no statistically significant change in sexual function after four to six months of treatment with finasteride 1mg (Propecia).

Interestingly, the research team found that sexual side effects were actually less common than reported in the clinical trials of the drug.

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Hair Restoration Research

10-Year Finasteride Study: First to Investigate Long-Term Effects and Safety

Posted by Robert M. Bernstein M.D. on August 20th, 2012

The 2011 study published by a research team led by Dr. Alfredo Rossi, is the first comprehensive investigation on long-term safety and efficacy of finasteride 1mg (Propecia).

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Hair Restoration Research

Sato Finasteride Study Points to Long-term Safety, Efficacy in Use of Propecia

Posted by Robert M. Bernstein M.D. on August 14th, 2012

Led by Dr. A. Sato, a Japanese team of medical researchers published the largest finasteride study ever performed, “Evaluation of efficacy and safety of finasteride 1mg in 3,177 Japanese men with androgenetic alopecia.” It investigated the effects of finasteride over a 3 1/2 year period in men with androgenetic alopecia, or common baldness.

The study found that patients who had experienced hair loss for an extended period of time and were treated with finasteride exhibited notable hair growth. While a fairly small proportion of patients with a hair loss duration over 10 years exhibited “greatly increased” growth, 85% of patients with hair loss duration of more than 15 years experienced “moderate” or “slightly increased” growth. Physicians have thought that people with advanced hair loss do not respond as well as patients in the early stages of hair loss. However, in light of the results of this study, that determination should be reconsidered. Continue reading this article.

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Hair Restoration Research

Summary Of Finasteride Label Changes

Posted by Robert M. Bernstein M.D. on May 31st, 2012

On April 11, 2012, the U.S. Food and Drug Administration (FDA) announced changes to the professional labels for Propecia (finasteride 1 mg) and Proscar (finasteride 5 mg) to expand the list of sexual adverse events reported to FDA as some of these events have been reported to continue after the drug is no longer being used (note that erectile dysfunction after stopping use of these drugs was added as a known event in 2011). The new label changes include:

  • A revision to the Propecia label to include libido disorders, ejaculation disorders, and orgasm disorders that continued after discontinuation of the drug.
  • A revision to the Proscar label to include decreased libido that continued after discontinuation of the drug.
  • A revision to both the Propecia and Proscar labels to include a description of reports of male infertility and/or poor semen quality that normalized or improved after drug discontinuation.

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Hair Restoration Research

Study: Latanoprost Might Be A Viable Hair Loss Medication

Posted by Robert M. Bernstein M.D. on May 18th, 2012

Journal of the American Academy of DermatologyA double-blind scientific study published in the May 2012 issue of the Journal of the American Academy of Dermatology has found that latanoprost, a drug that mimics naturally-derived compound molecules called prostaglandins, significantly increases hair density on the scalp after 24 weeks of treatment in young men with mild hair loss.

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Hair Restoration Research

Latisse Improves Eyelash Growth in Controlled Study

Posted by Robert M. Bernstein M.D. on May 16th, 2012

Journal of the American Academy of DermatologyLatisse, which is the brand name for the drug bimatoprost, has been found to effectively and safely grow eyelashes in a double-blinded scientific study published in the May 2012 issue of the Journal of the American Academy of Dermatology.

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Hair Restoration Research

Finasteride in the Treatment of Female Hair Loss

Posted by Robert M. Bernstein M.D. on March 10th, 2012

Synopsis: The discovery of the Androgen Receptor (AR) gene and related genes has expanded our knowledge on the genetics of common baldness (androgenetic alopecia). Recent basic science and clinical studies have lead to a better understanding of the pathogenesis of hair loss in both men and women. These genetic advances have lead to the development of a new screening test for androgenetic alopecia. In addition to the two currently approved FDA medications (minoxidil and finasteride) the FDA has approved a laser hair comb for the treatment of hair loss. Further studies are needed to verify the accuracy and validity of the genetic screening test and the efficacy of the laser hair comb.

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Hair Restoration Research

ISHRS: Scientific Data Backs Propecia Safety, Efficacy

Posted by Robert M. Bernstein M.D. on December 27th, 2011

In response to anecdotal evidence of sexual side effects continuing after stopping Propecia (finasteride 1mg), the International Society of Hair Restoration Surgery (ISHRS) has published a press release for the hair restoration community about the safety and efficacy of the drug. The release notes that scientific data gathered from extensive testing finds no correlation between persistent sexual dysfunction and Propecia.

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Hair Restoration Research

Latisse Drug as Hair Loss Treatment? Trials Under Way on New Formulation of Bimatoprost

Posted by Robert M. Bernstein M.D. on January 6th, 2011

Latisse, the brand name for the drug bimatoprost, is commonly used to promote eyelash growth in women who want their eyelashes to be longer, thicker, and darker, typically for cosmetic reasons.

In a publication on ClinicalTrials.gov, Allergan, the pharmaceutical company that produces Latisse, has announced a new study on the safety and efficacy of a new formulation of bimatoprost for use as a topical hair loss treatment for general baldness.

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