Research and updates on hair cloning and hair multiplication techniques.

Hair Restoration Research

Study Confirms Importance of Dermal Sheath Stem Cells in Hair Growth Cycle

Posted by Robert M. Bernstein M.D. on July 16th, 2015

Colony of self-renewing dermal sheath cells
Colony of self-renewing dermal sheath cells

New research published in the journal Developmental Cell has confirmed the importance of dermal sheath stem cells in maintaining the hair growth cycle. These cells, located around the lower portion of growing follicles, form the basis of an experimental treatment, being developed by Replicel Life Sciences, Inc., to regenerate hair-producing follicles. If successful, the treatment will be a game-changer for the hair restoration industry.

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Hair Restoration Research

Embryonic Stem Cell Hair Cloning May Hold The Key To Curing Baldness

Posted by Robert M. Bernstein M.D. on April 27th, 2015

New research has found that embryonic stem cells can be used to form a type of cell that induces new hair follicle growth, and that these cells promote robust hair growth when implanted into mice.

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Hair Restoration Research

Hair Cloning Researchers Outline Hurdles Towards Hair Loss Therapy

Posted by Robert M. Bernstein M.D. on February 24th, 2014

Dr. Claire Higgins and her colleague Dr. Colin Jahoda have published an overview of hair cloning and the challenges scientists face in attempting to develop hair regeneration therapies for androgenetic alopecia, or common balding. The article, published in Hair Transplant Forum International, points to two central problems in developing a hair loss therapy. The first is the difficulty in getting dermal papilla cells in humans to self-aggregate and form hair follicles and the second is the inability, thus far, of scientists to generate normal hairs and follicles.

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Hair Restoration Research

Hair Cloning Breakthrough with “Mass Production” of Epithelial Stem Cells

Posted by Robert M. Bernstein M.D. on February 6th, 2014

Progress towards hair cloning may have just have shifted up another gear thanks to scientists at the University of Pennsylvania and the New Jersey Institute of Technology. The breakthrough study published January 28th, 2014 is the first to show the successful transformation of adult human skin cells into quantities of epithelial stem cells necessary for hair regeneration.

The researchers, led by Dr. Xiaowei “George” Xu, started with human skin cells called dermal fibroblasts, then transformed those into a type of stem cell called induced pluripotent stem cells (iPSCs). These were then transformed into epithelial stem cells (EpSCs). This important step had never been achieved before in either humans or mice. The epithelial stem cells were combined with mouse dermal cells, that can be induced to form hair follicles, and then grafted on a mouse host. The epithelial cells and dermal cells then grew to form a functional human epidermis and follicles structurally similar to human hair follicles. The exhibits that accompany the study include photographic evidence of human hairs.

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Hair Restoration Research

Columbia University Study on 3-D Cultures is ‘Substantial Step Forward’ Towards Cloning Human Hair

Posted by Robert M. Bernstein M.D. on October 22nd, 2013

For four decades, scientists have known about the possibility of using cells derived from the base of hair follicles (dermal papilla cells) to stimulate the growth of new hair. More recently, researchers have been able to harvest dermal papillae, multiply them, and induce the creation of new hair follicles – but only in rats. Now, for the first time, scientists at Columbia University have shown that they can induce new human hair growth from cloned human papillae. This procedure, called “hair follicle neogenesis,” has the potential to solve one of the primary limitations in today’s surgical hair restoration techniques; namely, the patient’s finite donor hair supply that is available for transplantation.

A significant number of hair loss patients do not have enough donor hair to be candidates for a hair transplant procedure with the percentage of women lacking stable donor hair being greater than in men. This technique would enable both men and women with limited donor reserves to benefit from hair transplant procedures and enable current candidates to achieve even better results.

According to co-study leader Angela M. Christiano, PhD, of Columbia University in New York, the ground-breaking publication is a “substantial step forward” in hair follicle neogenesis. While the technology still needs further development to be clinically useful, the implications of successfully inducing new hair follicles to grow from cloned hair cells could be a game-changer in the arena of hair restoration. Instead of moving hair follicles from the donor area to the recipient area, as in a hair transplant, follicular neogenesis involves the creation of new follicles, literally adding more follicles to the scalp rather than merely transplanting them from one part of the scalp to another.

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Hair Restoration Research

Columbia University Scientist Induces Hair Follicle Growth from Dermal Papilla Implants

Posted by Robert M. Bernstein M.D. on September 27th, 2012

We have previously discussed Dr. Angela Christiano’s work on hair loss genetics with her team at Columbia University in New York. A review of the 16th annual meeting of the European Hair Research Society brings to our attention new research being conducted by a scientist who works at Dr. Christiano’s laboratory, Dr. Claire Higgins.

Dr. Higgins is studying the inductive properties of the dermal papilla (DP), which is a group of cells that forms the structure directly below each hair follicle.

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Hair Restoration Research

Japanese Researchers Bioengineer Hair Follicles from Stem Cells, Dermal Papillae

Posted by Robert M. Bernstein M.D. on September 21st, 2012

Japanese researchers have demonstrated that scientists can bioengineer viable, hair-producing follicles from epithelial stem cells and dermal papilla cells. Using these components, the team produced follicles that exhibit both the normal hair cycle and piloerection (the reflex contraction of a tiny muscle in the hair follicles which creates what is commonly referred to as “goose bumps”). The bioengineered follicles also developed the normal structures found within follicles and formed natural connections with skin tissues, muscle cells, and nerve cells.

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Hair Restoration Research

Hair Cloning Study Shows RepliCel’s Efficacy In Increasing Hair Density

Posted by Robert M. Bernstein M.D. on August 7th, 2012

RepliCel Life Sciences; a company out of Vancouver, Canada; is studying the use of hair cloning techniques to treat male pattern baldness and hair loss in women.

The study is in progress, but analysis of the 6-month interim results of the first phases have been published. As indicated in the graphic above, the preliminary results at 6 months show that vellus hair density has increased 24.9%, terminal hair density has increased 14.5%, overall hair density increased by 19.2%, and cumulative thickness per area increased by 15.4%.

Also, almost two-thirds of subjects (10 subjects out of 16, or 63%) received a greater than 5% increase in hair density at the injection site. Of that group of 10 subjects, 7 of them saw hair density improve by more than 10%, with the biggest improvement in hair density being an increase of 19.6% in one subject.

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Hair Restoration Research

RepliCel Hair Cloning Research Leads To Patents, Trials In Humans

Posted by Robert M. Bernstein M.D. on August 2nd, 2012

RepliCel Life Sciences; a company based in Vancouver, Canada; is investigating hair cloning techniques in order to develop a treatment for androgenetic alopecia, or common genetic hair loss.

Research conducted by the company’s scientific founders and lead scientists, Drs. Kevin McElwee and Rolf Hoffmann, has shown that a certain type of cell, called a dermal sheath cup cell, is integral in initiating the growth of mature hair follicles. This mechanism of follicle growth, when coupled with previous research on dermal papillae cells, is key to our understanding of hair loss and is a potential avenue for developing a treatment that could reverse hair loss.

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Hair Restoration Research

Hair Loss Cure A Possible Result Of Stem Cell Communication Research

Posted by Robert M. Bernstein M.D. on May 21st, 2011

Following some new research on stem cells, and their relationship with androgenetic alopecia (genetic hair loss), an article on stem cells and the way they organize hair growth was published in the April 29th issue of the journal Science. At issue is the way in which large numbers of stem cells coordinate the cycle of hair growth over thousands of hair follicles. How do all of those hair follicle stem cells know when to grow hair, and how do they know what their “neighbor” hair follicles are doing? Read more by viewing the full post.

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Hair Restoration Research

Progenitor Cells Could Play Key Role In Hair Loss Prevention, Cure

Posted by Robert M. Bernstein M.D. on May 18th, 2011

In the March/April 2011 issue of Hair Transplant Forum International we see a review of research on stem cells and progenitor cells, and another indication of the importance of this research in achieving the goal of being able to clone human hair. Read more about this exciting line of research.

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Hair Restoration Research

Hair Cloning Developments Possible With ACell Regenerative Medicine Technology

Posted by Robert M. Bernstein M.D. on October 26th, 2010

Hair cloning is one of the most hotly discussed topics in the field of hair transplantation today. “When will hair cloning become available?” and “How will it work?” are among the most frequently asked questions about treating hair loss that we receive at Bernstein Medical – Center for Hair Restoration.

New developments in regenerative medicine technology, presented at the 18th Annual Scientific Meeting of the International Society for Hair Restoration (ISHRS), may have opened the door to commercialization and medical use of new techniques which could provide an answer to both questions.

ACell, Inc., a company based in Columbia, Maryland, has developed and refined what they consider, “the next generation of regenerative medicine.”

For more information on this exciting development, view our page on ACell technology and hair cloning

Follow news and updates on our Hair Cloning News page.

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Hair Restoration Research

New Strategies for Tissue Regeneration

Posted by Robert M. Bernstein M.D. on August 6th, 2010

Two new avenues of scientific research, discussed in an article in the New York Times, might just help enable human beings to regenerate tissue. If we could tap into this capability, the possibilities for medical treatment are limitless. We could regrow an arm, a leg, a hand, repair a heart after a heart attack, or even regrow hair.

It is not a stretch to assume that if scientists can undo the inability of animals to grow heart muscle or limbs, we might someday be able to genetically reverse the inability of a bald person to grow hair.

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Hair Restoration Research

Hair Cloning Shows Promise in New Stem Cell Study

Posted by Robert M. Bernstein M.D. on July 30th, 2009

A new study, using hair cloning therapy to regrow hair, shows promise for all individuals suffering from alopecia areata. The study — conducted by Marwa Fawzi, a dermatologist at the University of Cairo Faculty of Medicine, and reported on Bloomberg.com — used stem cells from the scalps of eight children with alopecia areata to regenerate their own hair.

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Hair Restoration Research

Laminin-511 Stimulates Dermal Papilla for New Hair Growth

Posted by Robert M. Bernstein M.D. on August 8th, 2008

Through this study, it was shown that the signaling pathways introduced by the administration of noggin and sonic hedgehog alone were insufficient to develop a hair follicle. When Laminin-511 protein was introduced to the tissue culture, the dermal papilla developed. When the protein was inhibited, hair follicle growth again ceased. This information supports prior studies suggesting that Laminin is critical in the early stages of follicle cell development and is required for continued follicle development and growth.

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Hair Restoration Research

Strategies for Follicular Cell Implantation

Posted by Robert M. Bernstein M.D. on June 10th, 2008

Follicular cell implantation (FCI) is based on the ability of the dermal papilla (DP) cells, found at the bottom of hair follicles, to stimulate new hairs to form. DP cells can be grown and multiplied in culture, so that a very small number of cells can produce enough follicles to cover an entire bald scalp.

In order to produce new follicles, two types of cells must be present. The first are Keratinocytes, the major cell type in the hair follicle, and the second are dermal papillae cells (DP) which lie in the upper part of the dermis, just below the hair follicle. It appears that the DP cells can induce the overlying keratinocytes to form hair follicles. There are a number of proposed techniques for hair regeneration that use combinations of cells that are implanted in the skin. The two major techniques involve either transplanting dermal papillae cells by themselves into the skin, or implanting them with keratinocytes.

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Hair Restoration Research

Summary: Biologists Make Skin Cells Work Like Stem Cells

Posted by Robert M. Bernstein M.D. on June 12th, 2007

A major advance in regenerative medicine has recently been announced. A new technique, which can convert adult skin cells into embryonic form, has been successfully performed on interbred mice by Dr. Shinya Yamanaka of Kyoto University. The technique, if adaptable to human cells could allow new heart, liver, or kidney cells to be regenerated from simple skin cells. This tissue could potentially replace organ tissue that has been damaged due to disease. As this tissue would be formed from the patient’s own skin cells, it would not be subject to rejection by the patient’s immune system.

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Hair Restoration Research

Skin Cells Substitute for Embryonic Stem Cells in Cloning Research

Posted by Robert M. Bernstein M.D. on May 19th, 2007

The advantage of using embryonic stem cells in cloning research, organ transplantation, and in finding cures for disease, is that these cells are basically “unprogrammed.” This means that the stem cell has not yet determined what it will grow to become so, in theory at least, scientists can manipulate them into becoming anything that they are programmed to be.

Two teams of scientists working independently announced that they had successfully replicated the biological abilities of the embryonic stem cell using only skin cells.

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Hair Restoration Research

Summary: Hair Follicle Regeneration in Adult Mouse Skin After Wounding

Posted by Robert M. Bernstein M.D. on May 19th, 2007

This study demonstrates that after wounding the skin of an adult mouse, an embryonic-like change in the epidermal cells outside of the hair follicle stem cells can be induced to form new hair follicle stem cells. In other words, these cells originate from epidermal skin cells in the wound, but then are able take on the characteristics of hair follicle stem cells and actually produce hair.

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Hair Restoration Research

U.K. Invests in Hair Cloning Research

Posted by Robert M. Bernstein M.D. on October 9th, 2006

The British Government has awarded Intercytex a grant to automate the production of their new hair regeneration therapy. Intercytex is a cell therapy company that develops products to restore and regenerate skin and hair. Intercytex has partnered with a private company, The Automation Partnership (TAP), to develop an automated manufacturing process for their novel hair multiplication treatment.

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Hair Restoration Research

Summary: Hope Grows For Bald Baby Boomers

Posted by Robert M. Bernstein M.D. on November 25th, 2005

An English based company called Intercytex has claimed some success in its research on hair cloning with its first testing in humans. This technique is similar to the one initially proposed by Dr. Colin Jahoda and published in 1999.

The idea is that certain cells (called fibroblasts) found at the bottom of hair follicles can be separated from the follicles after they have been removed from the scalp, and then be used to form new follicles.

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Hair Restoration Research

Hedgehog Signaling Pathway Could Yield Hair Growth, Hair Loss Treatment

Posted by Robert M. Bernstein M.D. on February 17th, 2005

This study also demonstrated that the Hedgehog agonist is active in human scalp in vitro as measured by Hedgehog pathway gene expression. The results suggest that topical application of a Hedgehog agonist could be effective in treating hair loss conditions, including male and female pattern genetic hair loss.

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