Posts Tagged: Blood Supply to Scalp

Which Hair Loss Treatment is Better: Minoxidil with Retin-A or Minoxidil Without Retin-A?

November 9th, 2009

Q: Is using Minoxidil combined with Retin-A better than regular Minoxidil for Hair Loss?

A: Minoxidil has been prescribed (off-label) in combination with other medications, such as topical retinoic acid (Retin-A), to enhance its penetration into the skin and thus increase its effectiveness. This combination of medications, however, can significantly increase the absorption of minoxidil into the bloodstream and may increase the risk of potential side effects, including changes in blood pressure and severe scalp irritation that has, on occasion, led to scarring.

If person wants to add Retin-A to the minoxidil regime, the Retin-A should be applied only once a day, since the Retin-A will bind to the skin and will last for at least 24 hours.

Applying Retin-A more frequently will not increase its effectiveness (in facilitating the absorption of minoxidil); it will only increase the incidence of side effects. Retin-A can be applied to the scalp at the same time as Minoxidil, or by itself.

Retin-A should not be compounded with minoxidil (mixed together by your pharmacist or your doctor) for the following reasons:

  1. Minoxidil works best when used twice a day. Retin-A is best used once a day.
  2. Using Retin-A twice a day wastes money and increases the incidence of side effects
  3. If you develop side effects from the Retin-A, it is best to stop only the Retin-A. If they are compounded, you would need to stop both and will lose the benefit of minoxidil.

Explore the pro’s and con’s of Minoxidil — also known by its over-the-counter product Rogaine — at the Rogaine/Minoxidil page on the Bernstein Medical – Center for Hair Restoration website or by viewing minoxidil-related posts on the Hair Transplant Blog.


Posted by bwerner at 1:50 pm

After Hair Transplant, How Long Until One Can Resume Smoking?

April 11th, 2007

Q: I had my hair transplant done 10 days back, I was a regular smoker (8-10) cigarettes everyday from last 10 years. I have stopped smoking from the day of my surgery, how long should I stop smoking after surgery?

A: I would wait a minimum of 10 days, but the longer the better.

The nicotine in the smoke constricts blood vessels and decreases the oxygen to the tissues and the carbon dioxide in smoke displaces the oxygen.

Both chemicals retard healing.


Posted by Robert M. Bernstein M.D. at 10:49 am

In Your Hair Transplant Procedures, Do You Do Megasessions or Very Large Graft Sessions?

March 16th, 2007

Q: Some surgeons are doing hair transplants using 5,000 to 6,000 grafts in a single surgery. Looking at the cases in your photo gallery, it seems like your hair transplants involve many fewer grafts per surgery. Do you do such large graft numbers in a single hair restoration procedure?

A: The goal in surgical hair restoration should be to achieve the best results using the least amount of donor hair (the patient’s permanent reserves) and not simply to transplant the most grafts in one session. In my opinion, although large sessions are very desirable, the recent obsession with extremely large numbers of grafts in one session is misplaced. The focus should be on results.

For example, I would prefer to have full growth with a properly placed 2,500 – 3,000 graft hair transplant session than partial growth in a 5,000 graft session. Of course, the 5,000 graft session will look fuller than 2,500 grafts but, in my experience, never twice as full, and never as full as two 2,500 graft sessions.

The ability to perform large sessions is possible because of the very small recipient sites needed in Follicular Unit Transplantation (FUT). It is one of the main reasons that we developed this procedure in back in 1995. See the first paper on this subject: Follicular Transplantation.

However, like all good things, the technique loses some of its advantage when taken to extreme.

In “very” large sessions, the long duration of surgery, the increased time the grafts are outside the body, the increased amount of scalp wounding, risk of poor growth, wider donor scars, placing grafts where they are not needed, sub-dividing follicular units, and the decreased ability to plan for future hair loss, can all contribute to suboptimal results. These problems don’t always occur, but the larger the session, the greater the risk. Therefore, it is important to decide if one’s goal is simply to transplant the maximum amount of hair that is possible in one session, or to get the best long-term results from your hair restoration.

Follicular Unit Preservation

One of the most fundamental issues is that doctors using very large sessions are not always performing “Follicular Unit Transplantation” and, therefore, in these situations the patients will not achieve the full benefit of the FUT procedure. Although doctors who perform these very large sessions take the liberty of calling their surgery “Follicular Unit Transplantation,” in actuality it is not, since naturally occurring follicular units are not always kept whole. The procedure is defined as follows: “Follicular Unit Transplantation is a method of hair restoration surgery where hair is transplanted exclusively in its naturally occurring, individual follicular units.” (see Hair Transplant Classification)

By preserving follicular units, FUT maximizes the cosmetic impact of the surgery by using the full complement of 1 to 4-hairs contained in naturally occurring follicular units. A whole follicular unit will obviously contain more hair than a partial one and will give the most fullness. Keeping follicular units whole also insures maximal growth since a divided follicular unit loses its protective sheath and risks being damaged in the dissection.

It can sound impressive to claim that you performing very large hair transplants, but if the large numbers of grafts are a result dividing up follicular units, then the patient is being short-changed. The reason is that, although the number of grafts is increased, the total number of hairs transplanted is not. A 3-hair follicular unit that is split up into a 1-hair and 2-hair micro-graft will double the graft count, but not change the total number of hairs actually transplanted. In fact, due to the increased dissection, more fragile grafts, and all the other potential problems associated with very long hair transplant sessions, the total number of hairs that actually grow may be a lot less. Please look at the section “Limits to Large Hair Transplant Sessions” on the Graft Numbers page of the Bernstein Medical – Center for Hair Restoration website for a more detailed explanation of how breaking up follicular units can affect graft counts.

Donor Scarring

Since there are around 90 follicular units per cm2 in the donor scalp, one needs a 1cm wide by 28cm long (11inch) incision to harvest 2,500 follicular units. A 5,000 follicular unit procedure, using this width, would need to be 22 inches long, but the maximum length one can harvest a strip in the average individual is 13 inches (the distance around the entire scalp from one temple to the other).

In order to harvest 5,000 grafts, one would need 5,000 / 90 FU/cm2 = 55.6cm2 of donor tissue. If one takes the full 13 inch strip (33cm), then it would need to be 1.85 cm wide (55.6cm2 / (33cm long) = 1.85cm wide) or 1.85/2.54= ¾ of an inch wide along its entire length. However, one must taper the ends of a strip this wide (you can’t suture closed a rectangle) and, in addition, you can’t take such a wide strip over the ears. When you do the math again, it turns out that for most of the incision, the width must be almost an inch wide, an incredibly large amount of tissue to be removed in one procedure.

This large incision obviously increases the risk of having a wide donor scar – probably the most undesirable complication of a hair transplant. Needless to say, very large graft counts are achieved by sub-dividing follicular units rather than exposing the patient to the risk of an excessively large donor incision.

Popping

There are other issues as well. Large sessions go hand-in-hand with very high graft densities, since you often need these densities to fit the grafts in a finite area. The closer grafts are placed together, the greater the degree of popping. Popping occurs when a graft that is placed in the skin causes an adjacent one to lift-up. When a graft pops (elevates above the surface of the skin) it tends to dry out and die. Some degree of popping is a normal part of most hair transplant procedures and can be easily controlled by a skilled surgical team, but when it is excessive it can pose a significant risk to graft survival.

The best way to decrease the risk of popping being a significant problem is to not push large sessions (and the associated very dense packing) to the limit. In a patient’s first hair restoration procedure, it is literally impossible to predict the likelihood of excessive popping and once a very large strip is harvested, or the recipient sites are created in a very large session, it may be too late to correct for this. In addition, popping can vary at different times during the procedure and in different parts of the scalp adding to the problem of anticipating its occurrence.

Even if the distribution of grafts is well planned from the outset, a very large first session may force the surgeon to place hair in less-than-optimal regions of the scalp when popping occurs. This is because the surgeon must distribute the grafts further apart and thus over a larger area to prevent popping.

Blood Flow

Particularly where there is long-standing hair loss, the blood flow to the scalp has decreased making the scalp unable to support a very large number of grafts. This is not the cause of the hair loss, but the result of a decreased need for blood when the follicles have disappeared. In addition, persons that have been bald for a long time often have more sun damage on their scalp, a second factor that significantly compromises the scalp’s blood supply and may compromise the follicles survival when too many grafts are placed in one session. As with popping, the extent of photo-damage, as seen when the scalp gets a dusky-purple color during the creating of recipient sites, often only becomes evident once the procedure is well under way.

In the healing process following the first hair transplant, much of the original blood supply returns and this makes the scalp able to support additional grafts (this is particularly true if one waits a minimum of 8-10 months between procedures). This is another reason why it is better to not to be too aggressive in a first session when there is long-standing baldness or significant photo damage and where the blood supply may be compromised.

Limited Donor Supply

Another issue that is overlooked in performing a very large first session is that the average person only has about 6,000 movable follicular units in the donor area. When 5,000 grafts are used for the 1st procedure there will be little left for subsequent sessions and limit the ability of the surgeon to increase density in areas such as the frontal forelock or transplant into new areas when there is additional hair loss.

Conclusion

There are many advantages of performing large hair transplants, including having a natural look after one procedure, minimizing the number of times the donor area is accessed, and accomplishing the patient’s goals as quickly as possible. However, one should be cautious not to achieve this at the expense of a wider donor scar, poor graft growth, or a compromised ability to plan for future hair loss.

Achieving very high graft numbers should never be accomplished by dividing up the naturally occurring follicular units into smaller groups, as this increases the risk to the grafts, extends the duration of surgery, increases the cost of the procedure (when charging by the graft) and results in an overall thinner look.

For further discussion see:


Posted by Robert M. Bernstein M.D. at 2:34 pm

Do You Use Sutures or Staples in Hair Transplant?

February 22nd, 2007

Q: Can you please comment on the use of sutures verses staples in hair restoration procedures?

A: Sutures are great on non-hair bearing skin and allow perfect approximation of the wound edges, but on the scalp they can cause damage to hair follicles below the skin’s surface. The reason is that a running (continuous) suture traps hair follicles and when the skin swells (as it normally does after hair transplants) the trapped follicles can strangulate and die.

Since staples are placed individually – about ½ cm apart – they don’t strangle the tissue. This allows the blood supply to flow freely to the wound edge permitting the blood’s oxygen to reach the follicles in the stapled area and minimizing the risk of any hair loss. The unimpeded blood flow also facilitates wound healing and can sometimes result in a finer scar, particularly in a tight scalp.

For these reasons, we now use staples in most of our hair transplants.


Posted by Robert M. Bernstein M.D. at 8:32 am

Is Success of Hair Transplant Affected by Age or Scalp Fibrosis?

July 11th, 2006

Q: It is my understanding that as a person loses his or her hair, the skin of the scalp undergoes a number of changes, namely there is a loss of fat, an increase in cellular atrophy, and of course the dreaded perifollicular fibrosis (now that’s a mouthful). It seems to me that these changes, in particular the fibrotic scarring, are the main obstacles in the way of regrowth, and the reason Propecia does not work for extensively bald men. What can be done about this demon we call fibrosis? Can it be slowed, stopped, prevented, reversed? If we could somehow counteract collagen formation, wouldn’t our baldness problems be solved for good? If a bald scalp is atrophic, how does it have the capacity to hold a whole new head of transplanted hair? Is there a limitation to the number of hairs we can transplant (outside of donor limitations)?

A: The findings that you are describing are well documented; however, it is not clear if these changes are the cause of the hair loss or are the result of having lost one’s hair. Most likely, the DHT causes the hair follicles to miniaturize and eventually disappear. This, in turn, causes the scalp to thin and lose its abundant blood supply (whose purpose is to nourish the follicles). The changes in the scalp are also affected by normal aging, which causes alterations in connective tissue including the breakdown of collagen and other components of the skin. The changes seen with aging are greatly accelerated by chronic sun exposure.

Fortunately, even with long-standing baldness there is still enough blood supply to support a hair transplant, although there are some limitations. One should perform a hair transplant with a lower density of grafts when patients have thin, bald fibrotic scalps since the blood supply is diminished.

The most important factor, however, is photo change. The sun dramatically alters the connective tissue making the grafts less secure in their sites and alters the vasculature, (blood vessels) decreasing tissue perfusion (blood flow to the tissues). When there is bald atrophic, sun damaged scalp, I generally perform two hair transplant sessions of lower density (in place of one) spaced at least a year apart to give time for the scalp to heal and blood flow to increase in the area.

I often have the patient treated with topical 5-flurouracil before the surgery to improve the quality of the skin and to treat or prevent pre-cancerous growths from the sun.


Posted by Robert M. Bernstein M.D. at 1:08 pm



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