Q: I hear you leave staples in sometimes up to three weeks. Why do you leave staples in that long?

A: My reason for leaving some staples in longer is that the tensile strength of the wound continues to increase (significantly) during the first three week period after surgery — actually, it will continue to gain strength for up to one year post-op. To give the wound the best chance to heal, on average, I take out alternating staples at 10 days and the remaining staples at 20 days.

Although patients do complain that they are uncomfortable, removing half at 10 days offers enough relief for those who are bothered by them. The advantage of leaving the staples in longer is that the wound heals with a finer scar. And for patients who are very active, it allows them to resume activities more quickly. For each patient, I modify the time left in by surgery, length of incision, tension, and also the patient’s needs and ability to have them removed.

In contrast to sutures, staples do not leave any track marks and do not need to be removed as quickly. Sutures can also damage the surrounding hair by strangulating the follicles. Staples are interrupted (placed individually), so they don’t cause damage to the follicles adjacent to the wound edge.

Read more details about our use of surgical staples on the Donor Area page.

 

Q: I heard that the sexual side effects of Propecia are irreversible. Is this true?

A: The sexual side effects of finasteride (Propecia) begin to subside soon after the medication is discontinued. This would make sense since the drug finasteride is a reversible inhibitor of DHT. Although it is possible for side effects to be persistent after stopping the medication, this situation seems to be very uncommon and a cause and effect relationship is still in question.

One should consider that sexual dysfunction is relatively common in the adult male population and millions of patients take finasteride. Thus, there is a likely probability that some patients on finasteride may experience sexual dysfunction unrelated to the medication and, therefore, when the medication is stopped, the side effects would not be expected to go away.

Another thing to consider is that once a patient experiences sexual dysfunction (from a medication or another reason) psychological factors may come into play that make the side effects persist, even though they are unrelated to the medication or other underlying cause that may now be gone.

It is important to keep in mind is that medication plays an important role in the prevention and treatment of androgenetic alopecia and decisions to use medications should be done thoughtfully and in an informed way. Blog postings can offer some subjective information, but they do not constitute true research and should be used in conjunction with the information provided by your physician and other informed sources.

Learn more about Propecia (finasteride) and other hair loss medication.

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Following some new research on stem cells, and their relationship with androgenetic alopecia (genetic hair loss), an article on stem cells and the way they organize hair growth was published in the April 29th issue of the journal Science.

At issue is not the conversion of hair follicle stem cells into the progenitor cells that stimulate hair growth, as with the prior research, but the ways in which large numbers of stem cells coordinate the cycle of hair growth over thousands of hair follicles. How do all of those hair follicle stem cells know when to grow hair, and how do they know what their “neighbor” hair follicles are doing?

The researchers studied hair growth patterns in rabbits and mice and discovered that certain types of molecules, which were previously known to act as a signaling mechanism for stem cells in maintaining an individual hair follicle’s growth cycle, were also important in enabling large groups of stem cells to coordinate their activity.

The scientists found that hair stem cells coordinate their regeneration with each other with the aid of a pair of molecular activator WNT and inhibitor BMP. When WNT and BMP signals are used repetitively among a population of thousands of hair follicles across the entire skin surface, complex regenerative hair growth behavior emerges via the process of self-organization.

Perhaps more importantly, they found that the stem cell communication pathway present in rabbits and mice is far more robust than in men and women.

“When each human hair follicle wants to regenerate, it can only count on itself; it’s not getting help from other follicles,” Chuong said. “But when a rabbit hair follicle regenerates, it can count on two inputs: its own activation, and the activation signal from its neighbors. Rabbits have a very active hair growth, and that is essential for their survival in the wild.”

The article suggests that if there was a way to manage that process in humans, or “turn back on” the stem cell communication process in human hair follicles, then a treatment could be developed which would substantially increase the number of hair follicles that produce healthy hair.

Read a summary of this new research at ScienceDaily.com.

For more discussion on recent research, visit the Hair Cloning topic on the Hair Transplant Blog.